ABSTRACT
Sex-cord stromal tumors of ovary account for 5~8% of all ovarian malignancies. This group of ovarian neoplasms is derived from the sex cords and the ovarian stroma or mesenchyme. Although they can occur in women of all ages, they tend to have peak incidence in those over age50. So they should be surgically managd with hysterectomy and bilateral salpingo-oophorectomy. The purpose of this study is to report the experience at Asan Medical Center, Department of Obstetrics and Gynecology, in 24 patients with ovarian sex-cord stromal tumortreated between May, 1989 and April, 1995. We analyzed the effect of histologic subtype, FIGO stage, age and management. The results were as follows: 1. In histologic subtypes, fibrothecoma(66.7%), granulosa cell tumor(20.8%), Sertoli-Leydig cell tumor(8.3%), others(4.0%) were counted in order. 2. The mean age of sex cord-stromal tumor was 44.0 years and 8 cases(33.4%) of tumors over the age of 50.0 years, 13 cases(54.2%) over the age of 40.0 years. 3. Main initial symptoms were abdominal pain(37.5%), asymptomatic cases(25.0%), abdominal mass palpation(16.6%), irregular menstruation(12.5%) in order. 4. Management was surgery only(91.7%), surgery and chemotherapy(8.3%). 5. The mean disease free survival was 30.6 months.
Subject(s)
Female , Humans , Disease-Free Survival , Granulosa Cells , Gynecology , Hysterectomy , Incidence , Mesoderm , Obstetrics , Ovarian Neoplasms , Ovary , Sex Cord-Gonadal Stromal TumorsABSTRACT
Sex-cord stromal tumors of ovary account for 5~8% of all ovarian malignancies. This group of ovarian neoplasms is derived from the sex cords and the ovarian stroma or mesenchyme. Although they can occur in women of all ages, they tend to have peak incidence in those over age50. So they should be surgically managd with hysterectomy and bilateral salpingo-oophorectomy. The purpose of this study is to report the experience at Asan Medical Center, Department of Obstetrics and Gynecology, in 24 patients with ovarian sex-cord stromal tumortreated between May, 1989 and April, 1995. We analyzed the effect of histologic subtype, FIGO stage, age and management. The results were as follows: 1. In histologic subtypes, fibrothecoma(66.7%), granulosa cell tumor(20.8%), Sertoli-Leydig cell tumor(8.3%), others(4.0%) were counted in order. 2. The mean age of sex cord-stromal tumor was 44.0 years and 8 cases(33.4%) of tumors over the age of 50.0 years, 13 cases(54.2%) over the age of 40.0 years. 3. Main initial symptoms were abdominal pain(37.5%), asymptomatic cases(25.0%), abdominal mass palpation(16.6%), irregular menstruation(12.5%) in order. 4. Management was surgery only(91.7%), surgery and chemotherapy(8.3%). 5. The mean disease free survival was 30.6 months.
Subject(s)
Female , Humans , Disease-Free Survival , Granulosa Cells , Gynecology , Hysterectomy , Incidence , Mesoderm , Obstetrics , Ovarian Neoplasms , Ovary , Sex Cord-Gonadal Stromal TumorsABSTRACT
Malignant germ cell tumore occur in children and young women in reproductive age, of all the germ cell maligaanci orily pure dysgerminiomas had a high cure rate prior to 1970. This was due to the exquisite wdioseneitivity of these tumors. Multiple agent chemotherapy has dramatieally improved the pr nosis af patients with malignant ovarian germ cell tumors. The purpose of this study is to report the experience at Aaan Medical Center, department of Obstetrics and Gynecology, in 16 patients withmalignant ovarian germ cell tumors treated between July, l989 and June, l994. We analyzed the effect of age, histolagic subtype, FIGO stage, surgical pmcedurse and regimens of chemotherapy, on the prognosis of thwe tumors. The results obtained were as follows: 1. In histologic subtypes, dysgenninoma(38.0%), endodermal sinus tumor(25.0%), squamous cell carcinoma arising in mature cystic teratoma(19.0%), mixed cell tumor(6.0%), immature teratoma(6.0%), malignant ectodermal tumor in mature cystic teratoma(6.0%), were counted in order. 2. No site predilection was identifed. 3. Main initial symptoms were abdominal distension(31.0%), abdominal pain(31.0%), abdominal mass palpation(25.0%), amenorrhea(6.0%) in order. 4. Multiple tumor markers were considered to be useful in diagnosis and follow up of malignant germ cell tumors of ovary. 5. The mean age of malignant ovarian germ cell tumors was 29.5 years, and 11 cases(69.3%) of tumors under the age of 30.0 years. 6. The survival rate seemed to be decreased with advancing FIGO stage.